This joint publication is the result of a 2-day conference on Security and Defence in the EU that took place as a common project of Martens Centre and De Gasperi Foundation in June 2022. Four panel discussions took place on “The new strategic concept and the war in Ukraine: charting NATO’s route in a changing geopolitical scenario”; “NATO’s future in uncertain times: a new political direction suited for a new era”; “The new security landscape in Europe, NATO’s Madrid Summit and the European Union”; “Time to invest in Security and Defence: political and technological opportunities in a competitive world”. The conference proceedings are an overview of the main discussion points of the panellists who attended the event.