In 2024, Czechia marks twenty-five years of NATO membership and twenty years in the EU, milestones that have significantly reshaped its political, economic, and security landscape, alongside the broader Central European region. This publication examines the implications of NATO and EU enlargement for Central European countries, highlighting Czechia’s pivotal role. It explores the region’s current geopolitical and socio-economic challenges, with a focus on Russia’s war in Ukraine and the complexities of regional security. The volume addresses cultural exchanges, economic cooperation, and the potential for enhanced diplomatic ties, especially between Czechia, Austria, and Germany. It also discusses the risks of democratic backsliding, low pluralism, and the under-representation of women in politics. The publication begins with an essay by former diplomat Jakub Forst-Battaglia and includes seven chapters that cover resilience strategies, regional cooperation, external influences on democracy, disinformation, migration, and political representation. This comprehensive analysis offers insights into Central Europe’s role in addressing contemporary European challenges.